Development of cholinergic modulation and graded persistent activity in layer v of medial entorhinal cortex.

Title: Development of Cholinergic Modulation and Graded Persistent Activity in Layer V of Medial Entorhinal Cortex Authors:

During muscarinic modulation, principal neurons from layer V of rat medial entorhinal cortex (mEC) respond to repeated applications of a brief stimulus with a graded change in persistent firing frequency. This pattern of discharge has been proposed to represent an intrinsic mechanism for short-term memory operations. To investigate the implementation of persistent activity in mEC during develop...

Cholinergic modulation of the resonance properties of stellate cells in layer II of medial entorhinal cortex.

In vitro whole cell patch-clamp recordings of stellate cells in layer II of medial entorhinal cortex show a subthreshold membrane potential resonance in response to a sinusoidal current injection of varying frequency. Physiological recordings from awake behaving animals show that neurons in layer II medial entorhinal cortex, termed "grid cells," fire in a spatially selective manner such that ea...

Effects of acetylcholine on neuronal properties in entorhinal cortex

The entorhinal cortex (EC) receives prominent cholinergic innervation from the medial septum and the vertical limb of the diagonal band of Broca (MSDB). To understand how cholinergic neurotransmission can modulate behavior, research has been directed toward identification of the specific cellular mechanisms in EC that can be modulated through cholinergic activity. This review focuses on intrins...

Distance and Activity-dependent Modulation of Spike Back-propagation in 3 Layer V Pyramidal Neurons of the Medial Entorhinal Cortex 4

Muscarinic Suppression of Excitatory Synaptic Responses in Layer II of the Entorhinal Cortex

Entitled: Muscarinic suppression of excitatory synaptic responses in layer II of the entorhinal cortex and submitted in partial fulfillment of the requirements for the degree of Masters of Psychology complies with the regulations of the University and meets the accepted standards with respect to originality and quality. The entorhinal cortex is thought to play a role in mechanisms mediating sen...